Comparison of CKD-EPI, C-G and MDRD equations for estimating glomerular filtration rate in chronic kidney disease population in South-Western Nigeria

Background: Ethnic variabilities make reliability of formula equations for assessing glomerular filtration rate (GFR) doubtful in many populations. We compared Cockroft-Gault (CG), modification diet renal disease (MDRD), and chronic kidney diseases epidemiology collaboration (CKD-EPI) adult Nigerian CKD subjects.
 Methodology: measured 24-hour-urinary creatinine clearance 311 patients with the three estimated equations. Bland-Altman plots were used to assess agreement between (mGFR). Receiver-operating curve (ROC) analysis was diagnostic power Equation accuracy within 30% mGFR ≥90% considered acceptable use.
 Results: Mean age 41.9±12.7 years 182(58.5%) females. The mean GFR using CKD-EPI, 2 MDRD CG 69.5±33.9, 65.9±33.0 66.2±30.9 mls/min/1.73m respectively (mGFR 68.3±31.1mls/min /1.73m ). 3 showed positive correlation (r=0.95) but CKD-EPI had least bias.
 Conclusion: All can be equation is preferable patients, especially GFR> 60mls/min.